Ultrasonic atomization of tissue and its role in tissue fractionation by high intensity focused ultrasound

Ultrasonic atomization of tissue and its role in tissue fractionation by high intensity focused ultrasound.

Atomization and fountain formation is a well-known phenomenon that occurs when a focused ultrasound wave in liquid encounters an air interface. High intensity focused ultrasound (HIFU) has been shown to fractionate a tissue into submicron-sized fragments in a process termed boiling histotripsy, wherein the focused ultrasound wave superheats the tissue at the focus, producing a millimetre-sized ...

Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model.

The clinical use of high intensity focused ultrasound (HIFU) therapy for noninvasive tissue ablation has been recently gaining momentum. In HIFU, ultrasound energy from an extracorporeal source is focused within the body to ablate tissue at the focus while leaving the surrounding organs and tissues unaffected. Most HIFU therapies are designed to use heating effects resulting from the absorption...

High-intensity focused ultrasound in the treatment of prostatic tissue.

OBJECTIVE Beginning in 1987, high-intensity focused ultrasound was investigated in the canine model to determine the feasibility of destroying prostate tissue. After demonstrating the ability to ablate prostate tissue reliably in a canine model, a 15-patient pilot clinical study was undertaken at Indiana University in the fall of 1992. This pilot study was undertaken to assess the safety in the...

Nonlinear absorption in biological tissue for high intensity focused ultrasound.

In recent years the propagation of the high intensity focused ultrasound (HIFU) in biological tissue is an interesting area due to its potential applications in non-invasive treatment of disease. The base principle of these applications is the heat effect generated by ultrasound absorption. In order to control therapeutic efficiency, it is important to evaluate the heat generation in biological...

Optimizing Ultrasonic Intensity for High Intensity Focused Ultrasound Therapy